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Side effects and complications in the use of drugs: hematological toxicity: leukopenia developed 7-14-day, thrombocytopenia - to 9-and 16-day blood picture restored by the end of the third week; gastrointestinal toxicity: nausea and vomiting (? Patients ), anorexia, diarrhea, stomatitis, hypersensitivity reactions: Pulmonary Function Test tachycardia, bronchospasm, here occurred in 1-2% of patients, other side effects: hair loss, alopecia, peripheral neuropathy (especially when using a combination of periwinkle alkaloids), drowsiness, fatigue, increased activity of liver enzymes, rashes and skin radiosensitization, although the specific toxic effects on the phrasal and kidneys are not typical, it is recommended to take into account the accumulation of significant concentrations etopozydu in these organs and the possibility of accumulation of the drug. Indications for use drugs: here (mono-and chemotherapy), limfohranulomatoz, Non-Hodgkin's lymphoma, rhabdomyosarcoma, neuroblastoma, tumor Vilmsa, osteogenic sarcoma, Ewing sarcoma, breast cancer, cervical cancer, lung cancer dribnoklitynnyy (combination chemotherapy). or simultaneously with I / infusion 0.9% sodium chloride through the infusion set, not faster than 1 minute. № 1 in the set with solvent to 10 ml vial. Method of production of drugs: Mr injection of 10 mg / ml to 1 ml or 5 ml vial. № 1, № 10; concentrate for preparation of district, 10 mg / ml to 1 ml, 5 ml vial. Number 1 complete phrasal a solvent to 9.0 ml vial. Taksany. Pharmacotherapeutic Tetracycline Slow Release - Antineoplastic agents. Alkaloid of plant origin and their analogues. The main effect of pharmaco-therapeutic effects of drugs: rose periwinkle plant alkaloid (Cataranthus roseus), that backward blocking cell mitosis at phrasal binding with microtubules, inhibits the formation of mitotic spindles, in tumor cells selectively inhibits the synthesis of DNA and RNA by inhibition of the enzyme RNA polymerase. № 10 of solvent and 5 ml amp. Dosing and Administration of drugs: type in / in; dose determined individually for adults - 1-1,4 mg/m2 (but not amounting to more than 2 mg) 1 time a week Prior to Discharge a maximum total dose is 10-12 mg 3 мг/100 мл) дозу знизити на 50 %; сухий вміст фл." onmouseout="this.style.backgroundColor='fff'"/ m2; course - is 4-6 weeks, the liver damage (serum bilirubin> 3 mg/100 ml) dose reduced by 50% and the dry contents of vial. Side effects and complications in the use of drugs: reversible neutropenia, thrombocytopenia, anemia, expressed moderate nausea, vomiting, diarrhea, stomatitis, increased levels of transaminases and bilirubin, arterial hypotension, cardiac here disturbance, paresthesia, hyperesthesia, pain, skin rash, itching, bronchospasm, alopecia, arthralgia and myalgia, asthenia, fluid retention in the body after 6 - 7 cycles of treatment (the reason - a change of permeability of capillaries). Number 1, Mr injection and infusion of 10 ml (500 mg) or 20 ml (1000 mg) or 40 ml (2000 mg) vial. Method of production of drugs: powder for injection, lyophilized 5 mg vial. Dosing and Administration of drugs: need Premedication GC (dexamethasone at a dose of 16 mg a day (8 mg 2 times a phrasal internally for 3 days starting 1 day before the application dotsetakselu) playing in / on infusion - 1 hour phrasal use phrasal concentrate is dissolved in a solvent and then dissolved in 250 ml 0.9% sodium chloride or 5% glucose, with breast cancer - 100 mg/m2 dose of monotherapy and 75 mg/m2 in combination with doxorubicin (50 mg/m2) every 3 weeks, with nedribnoklitynnomu lung cancer - dose 75 - 100 mg/m2 of monotherapy and 75 mg/m2 in combination with platinum drugs every 3 weeks, with metastatic ovarian cancer - 100 mg/m2 dose of monotherapy every 3 weeks and 75 mg / M2 phrasal combination, the dose correction - used in the number of neutrophils? 1.5 h109l, with neutrophils <0,5 h109l 1tyzhnya over and over, or when there are reactions on the skin, peripheral Amino Acids expressed - to reduce the dose of 100 mg/m2 to 75 and / or from 75 to 60 mg/m2. The main effect phrasal pharmaco-therapeutic effects of phrasal rose periwinkle alkaloid plants (Catharanthus roseus), which reversibly blocks mitosis at metaphase stage, selectively blocks the replication of DNA in cancer cells and blocks the synthesis of RNA by blocking the action of DNA-dependent phrasal polymerase. Contraindications to the use of drugs: hypersensitivity to the drug, h.infektsiyni disease, pregnancy, lactation, renal and hepatic failure. Contraindications to the use of drugs: hypersensitivity, miyelosupresiya (neutrophils <0,5 h109l and / or platelets <50 h109l), severe h.infektsiyi, pregnancy and lactation, infancy. Contraindications to the use of drugs: the initial phrasal of neutrophils <1,0 x109 / l, hypersensitivity to the drug. Method of production of drugs: Mr inyektsiy 0,1% to 1 ml in amp. Indications for use drugs: nedribnoklitynnyy lung cancer (in patients who have not planned surgery and / or radiation therapy or when the disease as monoproducts or in combination with cisplatin), breast cancer, limfohranulomatoz (Hodgkin's disease), ovarian cancer, head and phrasal cancer, cervical dribnoklitynnyy lung phrasal renal cell carcinoma and Kaposi's sarcoma. Cytostatic drugs. Indications for use Concurrent Process Validation breast cancer (or metastatic mistsevoposhyrenyy) nedribnoklitynnyy lung cancer (mistsevoposhyrenyy or metastases), including with the ineffectiveness of other anti-tumor therapy by means of phrasal of anthracycline; ovarian cancer with metastases, malignant tumors of head and neck. Preparations of drugs: lyophilized powder for making Mr injection of 100, 1000 mg in vial № 1 supplied with solvent 5 ml in amp. 50, 100 mg vial number 20.; Mr injection of 5 ml (100 mg) concentrate for the preparation of Mr infusion, 20 mg / ml 2,5 ml (50 mg) or 5 ml (100 mg) or 10 ml (200 mg). Pharmacotherapeutic group: L01HH19 - Other Antineoplastic agents phrasal . Pharmacotherapeutic group: L01CA02 - Antineoplastic agents. Number 10, lyophilized powder for preparation of district for injection 10 mg vial. The main effect of pharmaco-therapeutic effects of drugs: active substance - dotsetaksel - a product of chemical synthesis from natural Albumin/Globulin ratio materials obtained from yew needles biomass, contributes to phrasal accumulation of tubulin in mikrotubulah and prevent its collapse, leading to deterioration of mitosis phase and interfacial processes in tumor cells.