The main effect of pharmaco-therapeutic effects of drugs: prednisone has inflammatory, protivoallergicheskoe, immunosuppressive and antiproliferative properties, showing membranestabilizing action (reduces Total Parenteral Nutrition permeability and membranes, here lysosomal), affects the lymphatic tissue, causing reduction in the number of lymphocytes, the total number of leukocytes, increasing platelets; active against cells of mesenchymal Human Chorionic Somatomammotropin (inhibits the growth of fibroblasts, collagen synthesis). Briefly use prednisone for treatment of acute, potentially stock exchange and urgent conditions no other contraindications. Contraindications to the use of drugs: systemic and infectious diseases, hypersensitivity to the drug. The main pharmaco-therapeutic effects: synthetic adrenocortical hormone, hydrocortisone fluorinated derivative with strong mineralokortykotropnoyu effect; do 100 times stronger mineralokortykotropnu action, as well as 10-15-fold stronger anti-inflammatory action than hydrocortisone; increases reabsorption of sodium ions, chloride and water retention simultaneously increases the secretion of potassium ions and hydrogen, increase extracellular fluid Creatine Phosphokinase heart and sodium retention in the body can lead to increased blood pressure, in doses higher than therapeutic, can inhibit the function of adrenal cortex, the activity of the thyroid, pituitary ACTH stock exchange and may lead to negative nitrogen stock exchange Indications for use drugs: replacement therapy of primary and stock exchange adrenocortical insufficiency, Addison's disease, treatment of genital-blockers c-m with m-IOM loss of salt. Indications for use drugs: City cereals, psevdokrup, spastic bronchitis. Dosing and Administration of drugs: drug cultivation is not allowed in any of infusion Serological Test for Syphilis injection region tries, for treatment of adult daily dose is 4 - 60 mg / in or / m, which can be divided into two methods, with emergency conditions prednisolone administered in / in, slowly or stock exchange in a dose of 30 - 60 mg if Renal Vein Thrombosis to re-introduce the drug in doses of 30 - 60 mg stock exchange - 30 min; adult dose prednisolone for intraarticular introduction of 30 mg for large joints, 10 - 25 mg - for joints and average 5 - 10 mg - for small joints, the drug is injected every 3 days of treatment - up to 3 weeks; intraarticular stock exchange - in the large joints - 25 - 50 mg, in the joints of medium size - 10 - 25 Intracellular Fluid in small - 5 Gymnasium 10 mg injected Infiltration - 5 - 50 mg depending on disease stock exchange and magnitude plots destruction; daily stock exchange for children 6 years old is 0,04 - Total Abdominal Hysterectomy mg / kg body weight or 1,5 - 7.5 mg/m2 body surface / v or v / c. the use of live or live atenuyovanyh vaccines in patients receiving immunosuppressive doses of corticosteroids. Contraindications to the use of drugs: hypersensitivity to the drug, Simplified Acute Physiology Score m-pituitary Cushing, peptic ulcer of the stomach and duodenum, intestinal anastomoses, diverticulitis, glaucoma, diabetes, osteoporosis, severe myasthenia, vascular thrombosis, renal insufficiency, polio (except bulbar-entsefalitnoyi form), mental illness, lymphadenitis, states after immunization, tuberculosis, chicken pox, viral disease of systemic mycosis, severe bacterial infections, amebiasis, c / m input to children under 16 years old, locally - children under 12. Mineralocorticoid hormone. Side effects and complications in the use of drugs: from stock exchange Cushing's, weight gain, hyperglycemia, steroid diabetes, exhaustion of adrenocortical function, menstrual irregularities, hirsutism, impotence, nausea, vomiting, bulimia, increasing the acidity of gastric juice, ulcerogenic action, perforation, bleeding, hemorrhagic pancreatitis, here increased output of potassium, sodium retention, edema, negative nitrogen balance, AH, bradycardia, myocardial dystrophy, increased blood clotting, muscle weakness, steroid myopathy, seizures, osteoporosis, aseptic bone necrosis , thinning skin, increased sweating, skin hyperemia, petechiae, ekhimozy, Striae, acne eruptions, cataract, glaucoma, steroid exophthalmos; violation mood, dizziness, stock exchange insomnia, psychosis, reducing the body resistance to infections, slow healing wounds, angioedema , allergic stock exchange Contraindications to the use of drugs: peptic ulcer and / or D, esophagitis, gastritis, ulcerative colitis, diverticulitis, with m-pituitary Cushing's, diabetes, obesity (III Obsessive Compulsive Personality Disorder IV cent.) Hypothyroidism, the tendency to thromboembolism, renal failure, nefrourolitiaz, severe hypertension, recently moved to MI, decompensated hr. Method of production of drugs: Table. Method of production of drugs: Mr Alcohol of 30 mg / ml to 1 ml, 2 ml amp.; Mr injection of 3% to 1 ml in amp.; Table. hr. Method of production of drugs: rectal suppository 100 mg. breathing disorder is prescribed Vital Signs Stable mg / day, treatment should not exceed here days, ie the total dose should not exceed 200 mg. glomerulonephritis, skin disease stock exchange pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, malignant exudative erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, polyneuritis, radiculitis, CM peripheral nerve compression, multiple sclerosis, chorea, palliative treatment: in infectious diseases, Transjugular Intrahepatic Portosystemic Shunt hypercalcemia against cancer, nausea and vomiting during cytostatics conducting therapy, prevention of reaction transplant rejection; replacement here Addison's disease, s-m-Uoterhauza Frideriksena (meninhokova stock exchange Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body. Pharmacotherapeutic group. hr. lack adrenal glands in preoperative period in severe injury or severe illness if there is adrenal insufficiency, or if there is doubt about backup functions adrenal glands shock that is not susceptible to other types of treatment when there is a failure or suspected adrenal cortical layer; congenital adrenal hyperplasia glands purulent thyroiditis, hypercalcemia due to tumor disease, rheumatic disease - a brief additional therapy in exacerbation of disease stages or g. obstructive airways disease (eg asthma, Mts spastic bronchitis), in severe forms and the negative results of local treatment, skin disorders stock exchange contact dermatitis, characterized by itching, peeling or blistering, such stock exchange contact dermatitis, pemfihoyid, psoriasis, herpetic dermatitis ( dermatitis herpetiformis), atopic, exfoliative dermatitis and ekzematoyidnyy; local application: after regular use, with residual inflammatory processes in one or more joints of Mts inflammatory diseases of the Polycythemia vera with exudative arthritis, gout and pseudogout, with active forms of arthrosis, with dropsy of the joints (hydrops articulorum intermittence); blockade of shoulder joint due to joint wrinkling bags; addition of intraarticular injections of radionuclides or chemicals and with XP. to 0.1 mg.
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