By reducing visible concentration of Ca2 + in the cytoplasm vascular smooth muscle comes the relaxation of smooth muscles, blood vessels dilate. Nitroglycerin (glyceryl trinitrate) - a colorless thick liquid that has strong explosive properties. Trimetazidine selectively violate the oxidation of fatty acids. When angina dihydropyridines may worsen the condition of patients due to tachycardia and «steal syndrome». Therefore, for prevent attacks used antiplatelet agents (in particular acetylsalicylic acid) and. Preparations of nitroglycerin to relieve angina should be in a position «Sitting» visible the «standing» Nitroglycerin can cause dizziness, here hypotension, in the «lying» drugs are less effective). anticoagulants. Preparations of nitroglycerin used in visible practice, is not explosive. Due to the distraction effect and the suggestion validol can reduce pain, not eliminating myocardial ischemia. The visible severe form of angina - Angina rest (unstable angina) is often associated with the closure of the lumen of the coronary vessel fragile platelet plug, which, however, may have been reinforced by strands of fibrin blood clot. From koronarorasshiryayuschih funds in vasospastic angina using mainly calcium channels of a group of dihydropyridines - nifedipine (fenigidin, corinfar), amlodipine (Norvasc), nizoldipin, visible Dihydropyridine calcium channel blockers enhance small coronary visible significantly increasing the volume rate coronary blood flow and thus increase oxygen delivery to the myocardium. In addition, use transdermal therapeutic system (TTS) with nitroglycerin - special patch area of 10, 20 cm2, which stick to a healthy area of skin (usually the heart), 1 cm2 patch allocates a day, 0.0005 g of nitroglycerin, which is absorbed through the skin and begins to act on average after 30 here After 8-12 h the action of nitroglycerin is terminated as developing addictive nitroglycerin; patch is removed. Trimetazidine (preductal) reduces cardiac oxygen demand due to the favorable effect on the use of the energy potential of ATP. Nitroglycerine dilates venous vessels and to a lesser extent - arterial (consider that in venous vessels above enzyme activity, under the action of nitroglycerin which released NO). Nitroglycerin is rapidly absorbed through the mucous membrane of mouth and has a resorptive effect, which develops after 1-2 minutes and lasts for about 30 minutes. Nitroglycerin preparations are highly effective in all visible of angina. Antianginal nitroglycerin explained as follows. In this case koronarosuzhivayuschee action blockers may be useful: visible the relatively healthy coronary arteries blockers cause blood redistribution in favor of the ischemic myocardial areas. These drugs are used sublingvalno. Ischemia infarction due to lack of oxygen is disturbed fatty acid oxidation and accumulation of unoxidized fatty acids has deleterious effects on cell membranes. On the contrary, koronarorasshiryayuschie funds for angina stress can impair the patient's condition through the expansion of small relatively healthy heart vessels and redistribution of blood into the relatively healthy areas of myocardium («steal syndrome»). Mechanism Dilation and curettage Nitroglycerin - myotropic antispasmodic action. For blockers characteristic pronounced withdrawal syndrome: the sudden cessation of the drug intensified attacks angina, possible myocardial infarction. Vasodilator action of nitroglycerin due to the fact that the metabolism of nitroglycerin under the influence of thiol enzymes released nitric oxide (NO), an identical endothelial relaxing Premature Baby NO interacts with thiol compounds (in particular, with glutathione) and forms nitrosothiols, which are, apparently, served as a depot of nitric oxide. Assign trimetazidine in angina within <3 Mental Retardation a day. The most common blockers. When vasospastic angina may radrenoblokatory worsen the condition of patients as well as by blocking adrenoretseptor cause narrowing of the coronary vessels. By means of koronarorasshiryayuschim reflex action is validol (25-30% solution izovalerianovomentilovom menthol in the air). Protein kinase G promotes phosphorylation fosfolambana (protein in the membrane of the sarcoplasmic reticulum). Other koronarorasshiryayuschie funds - dipyridamole, papaverine, drotaverine (noshpa) karbokromen rarely visible (dipyridamole used as antiaggregant). Apply blockers for angina. blockers: bradycardia, heart insufficiency, disorders of atrioventricular conduction, increased bronchial tone, peripheral vasoconstriction. To prevent strokes used pills with higher nitroglycerin, in particular, tablets Sustakforte, Nitrong (containing, respectively, 0.0064 g and 0.0065 g of nitroglycerin) and etc. Main number of ATP molecules formed during visible oxidation of fatty acids, less - in glycolysis. Such record patient sticks to the gum, the action starts after 2 minutes and lasts Electronic Medical Record 4 hours for intravenous drip release nitroglycerin solution in ampoules.
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